Modeling: Antimicrobial Lipopeptides Form Micelles along Target Membranes
نویسندگان
چکیده
منابع مشابه
Short alkylated peptoid mimics of antimicrobial lipopeptides.
We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectru...
متن کاملBacterial membranes are the target for antimicrobial polysiloxane-methacrylate copolymer
Antibacterial polysiloxane polymers with pending tert-butylamine groups are a novel class of compounds that are compatible with silicone elastomers, but their mechanism of action is not well understood. The research into their action mechanism was conducted on a polysiloxane copolymer grafted with tert-butylaminoethyl methacrylate and covalently attached fluorescein. Fluorometric measurements r...
متن کاملThermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity.
Antimicrobial lipopeptides (AMLPs) are antimicrobial drug candidates that preferentially target microbial membranes. One class of AMLPs, composed of cationic tetrapeptides attached to an acyl chain, have minimal inhibitory concentrations in the micromolar range against a range of bacteria and fungi. Previously, we used coarse-grained molecular dynamics simulations and free energy methods to stu...
متن کاملAntimicrobial lipopeptides: in vivo and in vitro synthesis
The non-ribosomally assembled lipopeptides display a number of biological activities, including antibiotic, antitumor, immune-modulating and immune-suppressive activities. This review starts with general comments on antimicrobial peptides (AMPs), a large family of compounds that includes non-ribosomally assembled lipopeptides. Then, it brings together information on in vivo synthesis (biosynthe...
متن کاملAntimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.
Defensins are cationic, cysteine-rich peptides (Mr = 3500-4000) found in the cytoplasmic granules of neutrophils and macrophages. These peptides possess broad antimicrobial activity in vitro against bacteria, fungi, tumor cells, and enveloped viruses, and they are believed to contribute to the "oxygen-independent" antimicrobial defenses of neutrophils and macrophages. Pathophysiologic studies i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2015
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.12.506.1